Research Topics: breast and aesthetic surgery

Terence Myckatyn, MD, is a Professor of Plastic and Reconstructive Surgery at Washington University School of Medicine. He has grant-funded basic science, clinical science and translational research programs currently active. Currently, funded research includes :

  1. Shared decision making in breast reconstruction
    Along with his collaborators Mary Politi, PhD, Hedwig E. Lee, MA, PhD, Randi Foraker, PhD, MA, FAHA, FAMIA, and Margaret Olsen, PhD, MPH, Myckatyn has developed a web-based clinical decision aid to facilitate shared decision making in breast reconstruction. This decision aid, already tested in a published prospective randomized control trial incorporates both a sensitive risk prediction model as well as a tool to help patients work through their priorities for breast reconstruction. With funding from NIH/AHRQ this tool has been optimized for efficiency, usability, and content and will now be tested in a variety of care settings at multiple sites in the United States.
  2. Randomized control trial to compare acellular dermal matrices
    With Marissa Tenenbaum, MD, Myckatyn is conducting an industry-funded study that compares surgical and patient reported outcomes between two forms of acellular dermal matrices used in pre and postpectoral breast reconstruction.
  3. Randomized control trial to compare impact of antibiotic irrigation and cancer on microbiota of tissue expanders
    This study, funded by the Plastic Surgery Foundation, uses next generation sequencing and advanced microbiological techniques to analyze the impact of cancer and antibiotic irrigation on bacterial biofilm formation on breast tissue expanders. This work is performed in collaboration with Jennifer Walker, MD, and Blake Hanson, MD, at the University of Texas, Houston.
  4. Analysis of agglutination around breast implants
    This study, funded by the Plastic Surgery Foundation , explores the formation of bacterial agglutinins around breast implants – a transition phase between planktonic and biofilm bacteria, and a potential therapeutic target to prevent device-related infection. This work is performed in collaboration with Jennifer Walker, MD and Blake Hanson, MD, at the University of Texas, Houston.
  5. Genomics of breast implant associated anaplastic large cell lymphoma
    This study, funded by the Aesthetic Surgery Education Research Foundation, explores a potential genetic predisposition to development of BIA-ALCL in patients with macrotextured breast implants utilizing both whole genome and whole exome sequencing, FISH, and other genomic techniques. This work is performed in conjunction with Eric Duncavage, MD, and Neha Mehta-Shah, MD, in molecular pathology and oncology at Washington University.
  6. Metabolics of breast implant bacteria
    This study, funded by institutional funds, investigates whether particular small molecules – byproducts of bacterial and human metabolism like polypeptides and other molecules detectable by standard laboratory equipment – identifiable in seroma fluid around breast implants can diagnose or predict a clinically relevant infection in some cases, or, portend a benign scenario in other cases. Metabolomics is the study of metabolic byproducts that takes into account host-pathogen interactions. This work is performed in conjunction with Margaret A. Olsen, PhD, MPH, and Jeffrey P. Henderson, MD, PhD.
  7. Clinical studies
    Myckatyn has several ongoing clinical studies at any given time that investigate outcomes in either aesthetic surgery or breast reconstruction. He generally performs these with his partner Marissa Tenenbaum, MD.