Matthew Wood

Matthew D. Wood, PhD

  • Assistant Professor of Surgery

Graduate School

MS, Biomedical Engineering, Washington University, St. Louis, Missouri, 2005-2008

PhD, Biomedical Engineering, Washington University, St. Louis, Missouri, 2005-2009

Post Doctoral Education

Postdoctoral Research Fellow, Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada, 2009-2012.

Research Interests

Dr. Wood directs the Peripheral Nerve Research Laboratory at Washington University School of Medicine. He is interested in the study of peripheral nerve injury and regeneration. To treat and identify peripheral nerve injury, he is actively researching strategies such as cell-based drug delivery, neural tissue engineering, surgical options and targeted imaging to nerve. Specific projects of interest include strategies to identify peripheral nerve injury and regeneration, mechanisms of failure associated with long nerve grafts, and development of relevant therapeutics to treat nerve injury.

Active Grants

R01 NS051706  Mackinnon, S.E./Sakiyama-Elbert (PI)  2/15/11-1/31/17
NIH NINDS       
Role: Wood, M.D. (Collaborator)
Title: The Effects of GDNF on Peripheral Nerve Regeneration   
Goals: The current study uses viral delivery systems to control the levels of GDNF in the distal nerve stump during long graft regeneration.

Contact Information

Office Phone: 314-362-1275
Email: woodm@wudosis.wustl.edu
Office: Wohl Clinic, Rm 9945A

Selected Publications

Poppler LH, Ee X, Schellhardt L, Hoben GM, Pan D, Hunter DA, Yan Y, Moore AM, Snyder-Warwick AK, Stewart SA, Mackinnon SE, Wood MD. Axonal Growth Arrests After an Increased Accumulation of Schwann Cells Expressing Senescence Markers and Stromal Cells in Acellular Nerve Allografts. Tissue Eng Part A. 2016 Jul;22(13-14):949-61. Epub 2016 Jul 7.

Farber SJ, Hoben GM, Hunter DA, Yan Y, Johnson PJ, Mackinnon SE, Wood MD. Vascularization is delayed in long nerve constructs compared with nerve grafts. Muscle Nerve. 2016 Aug;54(2):319-21. Epub 2016 May 27.

Yan Y, Wood MD, Hunter DA, Ee X, Mackinnon SE, Moore AM. The Effect of Short Nerve Grafts in Series on Axonal Regeneration Across Isografts or Acellular Nerve Allografts. J Hand Surg Am. 2016 Jun;41(6):e113-21. Epub 2016 Feb 12.

Agenor A, Dvoracek L, Leu A, Hunter DA, Newton P, Yan Y, Johnson PJ, Mackinnon SE, Moore AM, Wood MD. Hyaluronic acid/carboxymethyl cellulose directly applied to transected nerve decreases axonal outgrowth. J Biomed Mater Res B Appl Biomater. 2015 Dec 1. [Epub ahead of print]

Marquardt LM, Ee X, Iyer N, Hunter D, Mackinnon SE, Wood MD, Sakiyama-Elbert SE. Finely Tuned Temporal and Spatial Delivery of GDNF Promotes Enhanced Nerve Regeneration in a Long Nerve Defect Model. Tissue Eng Part A. 2015 Dec;21(23-24):2852-64.

Tajdaran K, Gordon T, Wood MD, Shoichet MS, Borschel GH. A glial cell line-derived neurotrophic factor delivery system enhances nerve regeneration across acellular nerve allografts. Acta Biomater. 2016 Jan;29:62-70. Epub 2015 Oct 9.

Tajdaran K, Gordon T, Wood MD, Shoichet MS, Borschel GH. An engineered biocompatible drug delivery system enhances nerve regeneration after delayed repair. J Biomed Mater Res A. 2016 Feb;104(2):367-76. Epub 2015 Oct 15.

Roam JL, Yan Y, Nguyen PK, Kinstlinger IS, Leuchter MK, Hunter DA, Wood MD, Elbert DL. A modular, plasmin-sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere system for establishing growth factor gradients in nerve guidance conduits. Biomaterials. 2015 Dec;72:112-24. Epub 2015 Aug 31.

Hoben G, Yan Y, Iyer N, Newton P, Hunter DA, Moore AM, Sakiyama-Elbert SE, Wood MD, Mackinnon SE. Comparison of acellular nerve allograft modification with Schwann cells or VEGF. Hand (N Y). 2015 Sep;10(3):396-402.

Wood MD, Mackinnon SE. Pathways regulating modality-specific axonal regeneration in peripheral nerve. Exp Neurol. 2015 Mar;265:171-5. Epub 2015 Feb 11. Review.

Placheta E, Wood MD, Lafontaine C, Liu EH, Hendry JM, Angelov DN, Frey M, Gordon T, Borschel GH. Enhancement of facial nerve motoneuron regeneration through cross-face nerve grafts by adding end-to-side sensory axons. Plast Reconstr Surg. 2015 Feb;135(2):460-71.

Kemp SW, Chiang CD, Liu EH, Wood MD, Willand MP, Gordon T, Borschel GH. Characterization of neuronal death and functional deficits following nerve injury during the early postnatal developmental period in rats. Dev Neurosci. 2015;37(1):66-77. Epub 2015 Jan 13.

Placheta E, Wood MD, Lafontaine C, Frey M, Gordon T, Borschel GH. Macroscopic in vivo imaging of facial nerve regeneration in Thy1-GFP rats. JAMA Facial Plast Surg. 2015 Jan-Feb;17(1):8-15.

Kemp SW, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH. Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury. Neuroscience. 2015 Jan 22;284:202-16.

Placheta E, Hendry JM, Wood MD, Lafontaine CW, Liu EH, Cecilia Alvarez Veronesi M, Frey M, Gordon T, Borschel GH. The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair. Neurosci Lett. 2014 Oct 17;582:81-6. Epub 2014 Sep 8.

Please view the most current list of publications for Matthew Wood, PhD, on Pubmed.

(Disclaimer: This listing may not include all articles associated with this person and may include publications related to other persons with a similar name.)