Matthew Wood

Matthew D. Wood, PhD

  • Assistant Professor of Surgery

Graduate School

MS, Biomedical Engineering, Washington University, St. Louis, Missouri, 2005-2008

PhD, Biomedical Engineering, Washington University, St. Louis, Missouri, 2005-2009

Post Doctoral Education

Postdoctoral Research Fellow, Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada, 2009-2012.

Research Interests

Dr. Wood directs the Peripheral Nerve Research Laboratory at Washington University School of Medicine. He is interested in the study of peripheral nerve injury and regeneration. To treat and identify peripheral nerve injury, he is actively researching strategies such as cell-based drug delivery, neural tissue engineering, surgical options and targeted imaging to nerve. Specific projects of interest include strategies to identify peripheral nerve injury and regeneration, mechanisms of failure associated with long nerve grafts, and development of relevant therapeutics to treat nerve injury.

Active Grants

R01 NS051706  Mackinnon, S.E./Sakiyama-Elbert (PI)  2/15/11-1/31/17
NIH NINDS       
Role: Wood, M.D. (Collaborator)
Title: The Effects of GDNF on Peripheral Nerve Regeneration   
Goals: The current study uses viral delivery systems to control the levels of GDNF in the distal nerve stump during long graft regeneration.

Contact Information

Office Phone: 314-362-1275
Email: woodm@wudosis.wustl.edu
Office: Wohl Clinic, Rm 9945A

Selected Publications

Szynkaruk M, Kemp SWP, Wood MD, Gordon T, Borschel GH. Experimental and Clinical Evidence for Use of Decellularized Nerve Allografts in Peripheral Nerve Gap Reconstruction. Tissue Eng Part B Rev. 2013 Feb;19(1):83-96.

Wood MD, Gordon T, Kim H, Szynkaruk M, Phua P, Kemp SWP, Lafontaine C, Shoichet M, Borschel GH. Fibrin gels containing GDNF microspheres increase axonal regeneration after delayed peripheral nerve repair. Regen Med. 2013 Jan;8(1):27-37.

Wood MD, Kim H, Bilbily A, Kemp SWP, Weber C, Gordon T, Shoichet M, Borschel GH. GDNF released from microspheres enhances nerve regeneration after delayed repair. Muscle Nerve. 2012 Jul;46(1):122-4.

Jesuraj NJ, Nguyen PK, Wood MD, Moore AM, Borschel GH, Mackinnon SE, Sakiyama-Elbert SE. Differential gene expression in motor and sensory Schwann cells in the rat femoral nerve. Journal of Neurosci Research 2012 Jan;90(1):96-104. PMC3218296

Wood MD, Kemp SWP, Weber C, Borschel GH, Gordon T. Outcome measures of peripheral nerve regeneration. Special Issue on "Axotomy, Neuronal Plasticity and Recovery of Function." Invited Review. Ann Anat. 2011 Jul;193(4):321-33.

Moore AM, Wood MD, Chenard K, Hunter DA, Mackinnon SE, Sakiyama-Elbert SE, Borschel GH. Controlled Delivery of Glial Cell Line-Derived Neurotrophic Factor Enhances Motor Nerve Regeneration. J Hand Surg Am. 2010 Dec;35(12):2008-17.

Wood MD, MacEwan MR, French AR, Moore AM, Hunter DA, Mackinnon SE, Moran DW, Borschel GH, Sakiyama-Elbert SE. Fibrin Matrices with Affinity-based Delivery Systems and Neurotrophic Factors Promote Functional Nerve Regeneration. Biotechnol Bioeng. 2010 Aug 15;106(6):970-9.

Wood MD, Hunter DA, Mackinnon SE, Sakiyama-Elbert SE. Heparin-binding affinity-based delivery systems releasing nerve growth factor enhance sciatic nerve regeneration. Journal of Biomaterials Research: Polymer Edition. 2010;21(6):771-87.

Namani R, Wood MD, Sakiyama-Elbert SE, Bayly PV. Anisotropic mechanical properties of magnetically aligned fibrin gels measured by magnetic resonance elastography. J Biomech. 2009 Sep 18;42(13):2047-53. PMC2756967

Wood MD, Willits RK. Applied electric field enhances DRG neurite growth: Influence of stimulation media, surface coating, and growth supplements. Journal of Neural Engineering. 2009 Aug;6(4):046003.

Wood MD, Moore AM, Hunter DA, Tuffaha S, Borschel GH, Mackinnon SE, Sakiyama-Elbert SE. Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration. Acta Biomaterialia 2009 May;5(4):959-68. PMC2678870

Wood MD, Borschel GH, Sakiyama-Elbert SE. Controlled release of glial-derived neurotrophic factor from fibrin matrices containing an affinity-based delivery system. J Biomed Mater Res A. 2009 Jun 15;89(4):909-18.

Wood MD, Sakiyama-Elbert, SE. Release Rate Controls Biological Activity of Nerve Growth Factor Released from Fibrin Matrices Containing Affinity-Based Delivery Systems. Journal of Biomedical Materials Research Part A 2008 Feb;84(2):300-12.

Wood M, Willits RK. Short-Duration, DC Electrical Stimulation Increases Chick Embryo DRG Neurite Outgrowth. Bioelectromagnetics 2006 May;27(4):328-31.

Please view the most current list of publications for Matthew Wood, PhD, on Pubmed.

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